Which is the best Racetam? (2023)

What is the most effective racetam?

Oxiracetam holds promise as the most potent racetam, but more literature is necessary to understand how it works and verify the anecdotal benefits. That being said, piracetam and oxiracetam are good candidates for people looking to enhance memory formation and recall, focus, and concentration.

Oxiracetam – This water-soluble ampakine nootropic in the racetam-class of compounds modulates AMPA receptors. [x] Oxiracetam increases acetylcholine And boosts ATP synthesis in brain cells. Oxiracetam significantly improves cognition, memory, sensory perception, reflexes and motivation.

Oxiracetam is well absorbed from the gastrointestinal tract with a bioavailability of 56-82%. Peak serum levels are reached within one to three hours after a single 800 mg or 2000 mg oral dose, with the maximal serum concentration reaching between 19 and 31 μg/ml at these doses.

Oxiracetam is one of the three first-tier racetam compounds, being produced after both Piracetam and Aniracetam. Oxiracetam appears to enhance the release of excitatory neurotransmitters and can aid in memory formation, but lacks human studies. Oxiracetam is most often used forBrain Health.

Nefiracetam improves memory recall and formation. Most students have reported that Nefiracetam is the most effective racetam for studying with a calm focus. Users have experienced more motivation, have a better attention span, and less mental fatigue and apathy.

Research suggests ingredients found in Mind Lab Pro® - L-Tyrosine, Rhodiola Rosea, L-Theanine, and Citicoline - are natural dopamine boosters that can help balance neurotransmitter levels using your body's inherent mechanisms.

Oxiracetam encourages the use of acetylcholine in your brain. So when using Oxiracetam you must ensure you have adequate choline levels available to make acetylcholine. Most neurohackers stack Oxiracetam with a choline supplement like Alpha GPC or CDP-Choline.

Alpha-GPC is a choline-containing compound that increases acetylcholine levels in the brain. We recommend using 750 mg Oxiracetam and 300 mg Alpha-GPC one to two times daily for optimal effect.

Is oxiracetam safe?

Racetams, such as piracetam, oxiracetam, and aniracetam, are generally considered safe because of their low toxicity. However, a variety of self-reports and case studies show that racetams, rather than enhancing cognition, can have quite the opposite effect in the long term.

Oxiracetam dosage

This nootropic is most commonly found in tablets, capsules, or powders. The average oxiracetam user takes between 750-2,000mg per day, split into two doses. Typically, users take a dose first thing in the morning and another dose in the afternoon.

Coluracetam (MKC-231) is a racetam drug purported to be a cognitive enhancing drug. It is able to preserve choline uptake into neurons when they are otherwise impaired, but currently there is no evidence for inherent nootropic effects. Coluracetam is most often used forBrain Health.

Aniracetam & Other Racetams

With this stack, it's a good idea to also include a choline source so the effects would be more balanced. Before you stack racetams together, it's better to try them out separately first, just so you can feel out their effects and see what works for you.

Racetams are a class of drugs that have the same chemical backbone (a pyrrolidone nucleus). PIracetam is the “original” racetam. It was discovered in the late 1960s. Since then, more than twenty derivatives have been synthesized.

What are the best nootropics for depression?

Citicoline has proven to help with depressive disorders.

Hence why it is the best nootropic for depression out there. Specifically, one double-blind, randomized study included over 50 patients with Major Depressive Disorder.

The misuse of nootropics—any substance that may alter, improve, or augment cognitive performance, mainly through the stimulation or inhibition of certain neurotransmitters—may potentially be dangerous and deleterious to the human brain, and certain individuals with a history of mental or substance use disorders might ...

Getting enough sleep, exercising, listening to music, meditating, and spending time in the sun can all boost dopamine levels. Overall, a balanced diet and lifestyle can go a long way in increasing your body's natural production of dopamine and helping your brain function at its best.

Along with eating a balanced diet, many possible supplements may help boost dopamine levels, including probiotics, fish oil, vitamin D, magnesium, ginkgo and ginseng. This, in turn, could help improve brain function and mental health.

Caffeine is undoubtedly the most widely used nootropic. While most people don't think of their daily cup of coffee as a nootropic, they would probably admit that they're often looking to improve their focus or boost their energy with that cup of coffee. So, in a sense, they are using caffeine as a nootropic.

Phenylpiracetam is more potent than piracetam and is used for a wider range of indications. In combination with a vasodilator drug, piracetam appeared to have an additive beneficial effect on various cognitive disabilities.

Alpha-Glycerylphosphorylcholine (GPC)

L-alpha glycerylphosphorylcholine (alpha-GPC or α-GPC) nearly matches choline bitartrate in density but has one major significant advantage over standard choline supplements. That advantage being the ability to cross the blood-brain barrier.

Is Noopept a racetam?

Noopept (n-phenylacetyl-l-prolylglycine ethyl ester or GVS-111) is often included in the racetam-family of nootropic compounds. But is not a true “racetam” because it does not have a 2-oxo-pyrrolidine nucleus. Noopept was developed in Russia where it is called Ноопепт or GVS-111.

Phenylpiracetam hydrazide, also known as fonturacetam hydrazide, is a racetam that is a derivative of phenylpiracetam in which the amide group is replaced with a hydrazide group.

Glutamate regulators (Namenda®)

Glutamate regulators are prescribed to improve memory, attention, reason, language and the ability to perform simple tasks. This type of drug works by regulating the activity of glutamate, a different chemical messenger that helps the brain process information.

Others often stack it with Alpha GPC to achieve better results. Despite its low bioavailability, Noopept is more potent than Piracetam as it uses lower concentrations and its effects show up faster.

Piracetam is a synthetic nootropic that may boost mental performance. Its positive effects on the brain seem more apparent in older adults, as well as people with mental impairment, dementia, or learning disorders, such as dyslexia.

“Natural Choline from Egg Yolk Phospholipids Is More Efficiently Absorbed Compared with Choline Bitartrate; Outcomes of A Randomized Trial in Healthy Adults.” Nutrients, vol. 11, no. 11, Nov. 2019.

A 2021 study assessed the effects of alpha GPC on stroke risk over ten years. The study found that alpha GPC users were at a higher risk for a stroke than non-users. They also found that higher doses of alpha GPC increased the risk for stroke (Lee, 2021).

If you are looking for a mood boost and balance but with only mild memory effects, then taking aniracetam maybe your best option. However, if you want a general neuro health enhancement, then buy noopept.

Noopept kicks in within 20 minutes of ingesting it. Because of its bioavailability, Noopept is one of the fastest nootropics to take effect in the body. You'll enjoy maximum benefits of your dose within 60 minutes of ingestion, then its effects will quickly dissipate over a couple of hours.

Noopept administration led to the normalization of the GABA, glycine, and aspartate levels and an increase in the dopamine content.

How much Phenylpiracetam should I take?

Phenylpiracetam is taken at a dosage of 100-200mg acutely, and this dose is taken 2-3 times per day (totalling a daily range of 200-600mg). The lower range seems effective, but the optimal dosage is not yet known.

Phenylpiracetam is typically prescribed as a general stimulant or to increase tolerance to extreme temperatures and stress. Phenylpiracetam has been researched for the treatment of Parkinson's disease.

The stimulants adrafinil and modafinil are agonists at the noradrenergic postsynaptic (α₁) receptors. At doses that have alerting effects, these drugs are reported to have few side effects.